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A highly conservative, cyclically permuted, non-homologous exchange among three unrelated DNA sequences in
1Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA. LPOVIRK@gems.vcu.edu
International Journal of Radiation Biology
|December 16, 1998
Abstract:
Molecular analysis of a bleomycin-induced rearrangement of the aprt gene in CHO cells revealed that it consisted of a nearly perfect three-way exchange among non-homologous sequences, consistent with a mechanism involving cyclically permuted misjoining of the six ends of three double-strand breaks.