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A mutant of Mycobacterium smegmatis defective in dipeptide transport
1Department of Microbiology and Molecular Genetics, and Department of Surgery, UMDNJ/New Jersey Medical School, Newark, New Jersey 07103, USA.
Journal of Bacteriology
|December 16, 1998
Abstract:
A mutant of Mycobacterium smegmatis unable to use the dipeptide carnosine (beta-alanyl-L-histidine) as a sole carbon or nitrogen source was isolated. Carnosinase activity and the ability to grow on beta-Ala and/or L-His were similar in the mutant and the wild type. However, the mutant showed significant impairment in the uptake of carnosine. This study is the first description of a peptide utilization mutant of a mycobacterium.