Interferon-gamma receptor deficiency: relationship between genotype, environment, and phenotype (Review)

S Lamhamedi1, E Jouanguy, F Altare

  • 1Laboratoire INSERM U429, Pavillon Kirmisson, Hopital Necker Enfants Malades, Paris, France.

Summary

Interferon-gamma receptor 1 (IFNgammaR1) deficiency causes severe mycobacterial infections. This review explores how genetic and environmental factors influence varied symptoms in affected children.

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