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Hidradenitis suppurativa

T J Brown1, T Rosen, I F Orengo

  • 1Department of Dermatology, Baylor College of Medicine, and the Veterans Administration Medical Center, Houston, Tex 77030, USA.

Southern Medical Journal
|December 16, 1998
PubMed
Summary
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Hidradenitis suppurativa (HS) is a chronic skin condition causing painful lesions. Early surgical intervention is recommended due to the rarity of spontaneous resolution and the likelihood of progressive disability.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory skin disease characterized by abscesses, fistulas, and scarring.
  • It typically affects young women, with prevalence ranging from 0.3% to 4% in industrialized nations.

Purpose of the Study:

  • To review and synthesize current literature on hidradenitis suppurativa.
  • To provide comprehensive information on its epidemiology, pathogenesis, clinical presentation, diagnosis, treatment, and prognosis.

Main Methods:

  • Literature review of reliable sources.
  • Identification of information on epidemiology, pathogenesis, clinical manifestations, evaluation, differential diagnosis, treatment, complications, and prognosis of HS.

Main Results:

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  • HS is a follicular epithelium defect, not primarily bacterial or linked to obesity/hyperandrogenism.
  • Diagnosis involves suspecting HS in young adults with recurrent, deep lesions in flexural areas unresponsive to antibiotics.
  • Effective treatments include clindamycin, isotretinoin, and most effectively, wide excision with healing by granulation.

    • Conclusions:

    • Spontaneous resolution of HS is uncommon, and progressive disability is typical.
    • Early, definitive surgical treatment is advised for optimal patient outcomes.