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Related Experiment Videos

Clinical application of human egg cryopreservation

M J Tucker1, P C Morton, G Wright

  • 1Reproductive Biology Associates, Atlanta, Georgia 30342, USA.

Human Reproduction (Oxford, England)
|December 16, 1998
PubMed
Summary

Clinical egg cryopreservation shows limited success, with improved outcomes for donated eggs compared to patients' own. This technology offers cautious optimism for future fertility treatments.

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Area of Science:

  • Reproductive Medicine
  • Cryobiology

Background:

  • Clinical egg cryopreservation has been explored over a 4-year period.
  • Limited success has been reported with current cryopreservation techniques.

Purpose of the Study:

  • To evaluate the success rates of clinical egg cryopreservation.
  • To assess the viability and outcomes of frozen and thawed eggs.

Main Methods:

  • Eggs (mature and immature) were cryopreserved using slow freezing and rapid thawing.
  • Cryoprotectants included 1,2-propanediol and sucrose.
  • Insemination was performed using intracytoplasmic sperm injection (ICSI).

Main Results:

  • 55% of aged unfertilized mature eggs survived freezing.

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  • In donated egg cycles, cryosurvival was 24%, leading to five pregnancies, two ongoing.
  • For autologous egg freezing, mature egg cryosurvival was poor (2.2%), but 44% of sibling germinal vesicle (GV) stage eggs survived.
  • A normal infant was delivered from in-vitro matured GV eggs post-thaw.

    • Conclusions:

    • Egg cryopreservation demonstrates potential benefits, with higher success in donated eggs.
    • Further research and optimization are needed for autologous egg cryopreservation.
    • The technology warrants cautious optimism for future applications in fertility preservation.