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[The anti-ulcer action of dibunol (Tonarol)]
R F Zarudiĭ1, V A Myshkin, F S Zarudiĭ
1Bashkir State Medical University, Institute of Organic Chemistry, Russian Academy of Sciences, Ufa, Russia.
Eksperimental'Naia I Klinicheskaia Farmakologiia
|December 17, 1998
Abstract:
In experimental study of antiulcerative activity of dibunol on various models of gastric ulcers in rats the drug caused a marked antiulcerative effect in all of them, reduced the incidence of ulcer formation, and shortened the time of ulcer healing. In a model of "acetic" ulcer dibunol oil solution led to quick normalization of lipid peroxidation in the gastric mucosa, which was evidence of high antioxidant activity in cases of ulcer lesions.