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Further observations of true mosaic trisomy 17 ascertained in amniotic fluid cell cultures
M Djalali1, G Barbi, J Mueller-Navia
1Abteilung Medizinische Genetik, Universität, Ulm, Germany.
Prenatal Diagnosis
|December 17, 1998
Abstract:
Three new cases of true mosaic trisomy 17 (MT17) were diagnosed in amniotic fluid cells. Postnatal chromosome analysis from lymphocytes did not confirm the trisomic cell line, and follow-up studies showed normal psycho-motor development of the children, in one case up to the age of 4 1/2 years. We suggest that there are similarities between MT17 and MT20, in which the majority of pregnancies result in deliveries of healthy babies.
Insights
True mosaic trisomy 17 (MT17) diagnosed prenatally often resolves, with children showing normal development. This suggests MT17 may have a better prognosis than previously thought.
Area of Science:
- Genetics
- Prenatal Diagnosis
- Developmental Biology
Background:
- Mosaic trisomy 17 (MT17) is a rare chromosomal abnormality.
- Previous understanding suggested potential developmental concerns associated with MT17.