Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Existing treatment strategies: does noncompliance make a difference?

J J Caro1, J L Speckman

  • 1Caro Research, Concord, Massachusetts 01742, USA.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|December 17, 1998
PubMed
Summary

Choosing antihypertensive medications impacts patient adherence. Angiotensin-converting enzyme inhibitors showed the highest persistence and lowest discontinuation rates in a real-world study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Secondary prevention fallacy: pitfalls in comparing with primary.

Expert review of pharmacoeconomics & outcomes research·2009
Same author

The design of an observational study of hypertension management, adherence and pressure control in Blood Pressure Success Zone Program participants.

International journal of clinical practice·2008
Same author

Oxybutynin extended release and tolterodine immediate release : a health economic comparison.

Clinical drug investigation·2007
Same author

Postmarketing studies: benefits and risks.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2006
Same author

Care needs and economic consequences after acute ischemic stroke: the Erlangen Stroke Project.

European journal of neurology·2005
Same author

Economic evaluation of therapeutic interventions to prevent Type 2 diabetes in Canada.

Diabetic medicine : a journal of the British Diabetic Association·2004

Area of Science:

  • Pharmacology
  • Hypertension Management
  • Real-World Evidence

Background:

  • Poor patient compliance with antihypertensive medication is linked to uncontrolled blood pressure.
  • The relationship between specific antihypertensive treatment choices and patient compliance requires further investigation.
  • Real-world evidence is crucial as patient behavior in clinical trials differs from actual practice.

Purpose of the Study:

  • To review the literature on therapeutic choices and patient compliance with antihypertensive medications.
  • To analyze real-world data on treatment persistence and discontinuation rates for different antihypertensive drug classes.

Main Methods:

  • Literature review of studies on antihypertensive medication compliance.
  • Analysis of treatment data from the Saskatchewan provincial health plan.

Related Experiment Videos

  • Examination of patient persistence and discontinuation rates for various antihypertensive drug classes.

    • Main Results:

    • Angiotensin-converting enzyme inhibitors (ACE inhibitors) demonstrated the highest 1- and 4.5-year persistence rates.
    • ACE inhibitors were associated with the lowest discontinuation rates compared to calcium antagonists, beta-blockers, and diuretics.
    • The study highlighted differences in compliance between new and established hypertensive patients.

    Conclusions:

    • Treatment choice significantly influences patient compliance and persistence with antihypertensive therapy.
    • Angiotensin-converting enzyme inhibitors may be a preferred initial choice due to superior persistence and tolerability.
    • Findings have implications for physicians selecting initial antihypertensive treatments to improve blood pressure control.