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Related Experiment Videos

Soft lens extended wear affects epithelial barrier function

N A McNamara1, K A Polse, S A Fukunaga

  • 1Morton D. Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley 94720-2020, USA.

Ophthalmology
|December 17, 1998
PubMed
Summary
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Soft contact lens extended wear (SCLEW) significantly increases epithelial permeability to fluorescein (Pdc) within 2 weeks. This increased permeability, most pronounced in the morning, suggests potential risks associated with SCLEW.

Area of Science:

  • Ophthalmology
  • Corneal Physiology

Background:

  • Epithelial permeability is crucial for corneal health.
  • Soft contact lens extended wear (SCLEW) may compromise the ocular surface.

Purpose of the Study:

  • To investigate the impact of SCLEW on epithelial permeability to fluorescein (Pdc).
  • To assess the influence of eye closure on Pdc.

Main Methods:

  • Prospective cohort study involving 31 non-contact lens wearers.
  • Measured Pdc before and after 2, 4, and 12 weeks of SCLEW.
  • Evaluated Pdc during morning and afternoon measurements in non-wearers.

Main Results:

  • SCLEW significantly increased Pdc after 2, 4, and 12 weeks (P < 0.001).
  • A 99% increase in permeability was observed after 2 weeks of SCLEW.

Related Experiment Videos

  • Pdc was highest in the morning and decreased by approximately 12.5%/hour during the day.

    • Conclusions:

    • SCLEW elevates epithelial permeability, with significant changes occurring within 2 weeks.
    • Increased Pdc after SCLEW is most notable in the morning and diminishes throughout the day.
    • Further research is needed to determine if Pdc changes predict contact lens-associated keratopathy.