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[A new test for monitoring heparin therapy]
M Camici1, L Evangelisti, R Giordani
1Insegnamento di Semeiotica Medica, Università degli Studi, Pisa.
Minerva Medica
|December 18, 1998
Abstract:
A simple and easy assay for plasma heparin measurement (international units/ml) is described. The method is based upon the heparin neutralization and titration by polybrene. Heparin biological activity is measured first by activated partial thromboplastin time prolongment and then by means of polybrene titration: plasma heparin concentration was evaluated in international units/ml (IU/ml). The design and properties of this method are reported. Application in clinical practice of monitoring heparinization during hemodialysis is evaluated.