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No evidence for an effect of nutritional status at diagnosis on prognosis in children with acute lymphoblastic
J Weir1, J J Reilly, J H McColl
1University of Glasgow, Department of Human Nutrition, Yorkhill NHS Trust, Scotland, UK.
Insights
Nutritional status, measured by body mass index standard deviation score (SDS), does not impact the prognosis for childhood acute lymphoblastic leukemia (ALL). This study found no link between initial nutritional status and patient outcomes in ALL.
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Nutrition
Background:
- Childhood acute lymphoblastic leukemia (ALL) is a common pediatric cancer.
- Nutritional status is a critical factor in overall health and disease recovery.
- The role of nutritional status at diagnosis as a prognostic indicator in ALL requires further clarification.
Purpose of the Study:
- To investigate the relationship between nutritional status at diagnosis and prognosis in children with acute lymphoblastic leukemia (ALL).
- To determine if body mass index standard deviation score (SDS) is a significant prognostic factor in childhood ALL.
Main Methods:
- A cohort of 1,025 patients with standard-risk ALL was analyzed.
- Patients were randomized to different intensification therapy protocols.
- Survival analysis, including time to first relapse, was used to assess the influence of body mass index SDS.
Main Results:
- No statistically significant association was found between body mass index SDS and clinical outcome in childhood ALL.
- Survival analysis indicated no evidence that nutritional status at diagnosis affects relapse rates or time to relapse (p = 0.72).
Conclusions:
- Nutritional status, assessed by body mass index, does not appear to be a prognostic factor for childhood ALL in developed countries.
- Current findings suggest that body mass index at diagnosis should not be considered in predicting ALL prognosis.
Purpose:
To test the hypothesis that nutritional status at diagnosis, defined as body mass index standard deviation score (SDS), is related to the prognosis in childhood acute lymphoblastic leukemia (ALL).
Patients And Methods:
The sample consisted of 1,025 patients with standard risk ALL who had been randomized to different intensification therapies. Outcome measures were relapse/no relapse and time to first relapse. The influence of body mass index SDS was tested by survival analysis.
Results:
There was no evidence that body mass index SDS was related to clinical outcome (proportional hazards model, p = 0.72).
Conclusions:
The study results suggest that nutritional status at diagnosis, defined on the basis of the body mass index, at least in developed countries, has no effect on the prognosis in ALL, and it should not be considered as a prognostic factor.
