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Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11)
F Antillon1, F G Behm, S C Raimondi
1Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Journal of Pediatric Hematology/Oncology
|December 18, 1998
Summary
This report details an unusual case of pediatric primary lymphoma of bone (PLB) in an 11-year-old boy, characterized by a specific chromosomal translocation t(3;22)(q27;q11). The patient achieved complete remission after chemotherapy, highlighting successful treatment for this rare condition.
Area of Science:
- Pediatric Oncology
- Hematology
- Genetics
Background:
- Primary lymphoma of bone (PLB) is a rare malignancy in children.
- The t(3;22)(q27;q11) chromosomal translocation is uncommon in pediatric lymphomas.
Observation:
- An 11-year-old boy presented with back pain and a destructive S1 lesion with an epidural component.
- Histopathology confirmed diffuse large B-cell non-Hodgkin lymphoma.
- Karyotypic analysis revealed the t(3;22)(q27;q11) translocation.
Findings:
- The patient achieved a complete disease-free status 4 years post-treatment.
- Intensive systemic and intrathecal chemotherapy were effective.
Implications:
- This case highlights the importance of genetic analysis in pediatric bone lymphomas.
- The successful treatment outcome suggests that aggressive chemotherapy regimens can be effective for rare PLB subtypes.
- Further research into the BCL-6 gene's role in such translocations may be warranted.