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Pediatric primary diffuse large cell lymphoma of bone with t(3;22)(q27;q11)
F Antillon1, F G Behm, S C Raimondi
1Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Purpose:
A child with a primary lymphoma of bone (PLB) with a t(3;22)(q27;q11) is described.
Methods:
An 11-year-old boy had a 5-week history of back pain and a destructive lesion of S1 that contained an epidural component. Histologic evaluation of a biopsy confirmed the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Karyotypic analysis disclosed a t(3;22)(q27;q11), but the amount of tumor tissue was insufficient for molecular studies of the BCL-6 gene.
Results:
The patient remains free of disease 4 years after completion of intensive systemic chemotherapy and intrathecal chemotherapy.
Conclusions:
The lymphoma in the patient described in this report is highly unusual because of the coexistence of pediatric PLB and a t(3;22)(q27q11).