Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulation of integrin-mediated adhesion during cell migration

E A Cox1, A Huttenlocher

  • 1Department of Cell and Structural Biology, University of Illinois at Urbana-Champaign, Urbana 61801, USA. ea-cox@pop.life.uiuc.edu

Microscopy Research and Technique
|December 19, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishing an <i>ex vivo</i> porcine skin model to investigate the effects of broad-spectrum antiseptic on viable skin microbial communities.

mSphere·2025
Same author

Second harmonic generation microscopy in zebrafish.

Methods in cell biology·2016
Same author

Microfluidic device for simultaneous analysis of neutrophil extracellular traps and production of reactive oxygen species.

Integrative biology : quantitative biosciences from nano to macro·2016
Same author

Simple microfluidic device for studying chemotaxis in response to dual gradients.

Biomedical microdevices·2015
Same author

Long-term disease-free survival after nonmyeloablative cyclophosphamide/fludarabine conditioning and related/unrelated allotransplantation for acute myeloid leukemia/myelodysplasia.

Bone marrow transplantation·2010
Same author

Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid.

Journal of thrombosis and haemostasis : JTH·2004
Same journal

Deep Learning Based Framework for Detection and Classification of Leukemia Using Microscopic Images.

Microscopy research and technique·2026
Same journal

Externally Controlled In Situ SEM: Multi-Rate Scanning With Signal Regulation and Spatiotemporal Fusion.

Microscopy research and technique·2026
Same journal

In Situ TEM Observation of Phase Transformation Nucleation at the Near-Surface of Synthetic Aragonite.

Microscopy research and technique·2026
Same journal

Morpho-Anatomical and HPTLC Investigations of Lysimachia nummularia L. (Primulaceae) Grown in Switzerland.

Microscopy research and technique·2026
Same journal

Macroscopic, Histological and Ultrastructural Features of the Tongue of the Anatolian Wild Boar (Sus scrofa libycus).

Microscopy research and technique·2026
Same journal

Ultrastructural Insights Into the Reproductive Anatomy and Eggs of Cotton Pink Bollworm, Pectinophora gossypiella Saunders (Lepidoptera: Gelechiidae).

Microscopy research and technique·2026
See all related articles

Cell migration relies on regulated adhesion to the extracellular matrix (ECM). This review details how cell detachment at the rear, involving myosin, tyrosine phosphorylation, and calpain, drives fibroblast and neutrophil movement.

Area of Science:

  • Cell Biology
  • Biophysics
  • Biochemistry

Background:

  • Cell migration is crucial for development and disease.
  • Integrin-mediated adhesions to the extracellular matrix (ECM) are central to cell movement.
  • Understanding cell detachment at the rear of migrating cells is key.

Purpose of the Study:

  • To review recent advances in cell adhesion mechanisms regulating cell migration.
  • To focus on the process of cell detachment at the rear of migrating cells.
  • To discuss key regulators of cell adhesion and detachment.

Main Methods:

  • Literature review of recent research on cell migration and adhesion.
  • Analysis of molecular mechanisms involved in cell-ECM interactions.
  • Discussion of signaling pathways and mechanical forces.

Related Experiment Videos

Main Results:

  • Integrin-mediated adhesions are critical for cell migration.
  • Cell detachment at the rear involves complex regulation.
  • Key regulators include myosin contractility, tyrosine phosphorylation, Rho signaling, calcium fluxes, and calpain activity.

Conclusions:

  • Coordinated regulation of adhesive events is essential for directional cell movement.
  • Further research is needed to elucidate the spatial and temporal coordination of these adhesive events.
  • Understanding these mechanisms can provide insights into diseases involving cell migration.