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1,1-Bis-(1,2,4-triazolyl and 1,3,4-thiadiazolyl) ethane and phenylethane derivatives as potential antibacterial
A M Abdelal1, M M Gineinah, M N Nasr
1Department of Medicinal Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Bollettino Chimico Farmaceutico
|December 22, 1998
Abstract:
A series of compounds containing two identical heterocyclic moieties such as triazole and thiadiazole separated by ethane or phenylethane was synthesized. The structures of the newly prepared compounds were established on the basis of their elemental analyses and spectral data. The target compounds were subjected to antifungal and antibacterial screening. The results of this testing revealed that compounds 23, 26, 34 and 35 showed promising antibacterial activity, while, compound 33 showed remarkable antifungal activity.