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Fluorescein-induced allergic reaction
M P López-Sáez1, E Ordoqui, P Tornero
1Sección de Alergología y Medicina y Cirugia Experimental e Instituto Oftálmico, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Summary
Adverse reactions to sodium fluorescein during angiography are rare. Allergy testing revealed an IgE-mediated mechanism in one patient, suggesting true allergic reactions require thorough evaluation.
Area of Science:
- Ophthalmology
- Allergy and Immunology
Background:
- Intravenous sodium fluorescein is used in ocular angiography.
- Adverse reactions are uncommon, and their mechanisms are not fully understood.
Observation:
- A patient experienced dizziness, hypotension, and malaise during fluorescein angiography.
- Allergy evaluation included skin tests and serum tryptase levels.
Findings:
- The patient showed positive skin tests and a significant increase in serum tryptase.
- Control subjects tolerated the procedure without adverse reactions or tryptase elevation.
Implications:
- The findings suggest an IgE-mediated allergic mechanism for fluorescein adverse reactions.
- Complete allergy evaluations are recommended for patients experiencing adverse reactions to fluorescein.