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Updated: Aug 5, 2026

Preparation of Herbal Medicine: Er-Xian Decoction and Er-Xian-containing Serum for In Vivo and In Vitro Experiments
Published on: May 31, 2017
Pharmacokinetics of weekly transdermal estradiol controlled delivery system in postmenopausal Chinese
1Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, China.
Aim:
To study Pharmacokinetical profile of weekly transdermal estradiol controlled delivery system (E2-WTCDS) in 18 Chinese postmenopausal women.
Methods:
Single and multiple daily doses of E2-WTCDS were applied to an area of intact skin on the lower abdomen, using Estraderm TTS (E2-TTS) from Ciba-Geigy Company as control. E2 concentration in serum was measured by RIA.
Results:
Cmax 38 +/- 5 ng.L-1, Tmax 22 +/- 5 h, AUC 5651 +/- 386 ng.h.L-1, Cmax(SS) 44 +/- 7 ng.L-1, Cmax(SS) 35 +/- 4 ng.L-1, Fl 0.22 +/- 0.10. The relative bioavailability of E2-WTCDS was comparable to E2-TTS during the same period of system application.
Conclusion:
E2-WTCDS maintained relatively constant and effective serum estradiol concentrations and is suitable for once-weekly application.
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