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Diltiazem concentrations in plasma vs PR intervals on electrocardiogram in 8 men
1Centre of Metabolism & Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Aim:
To develop an acute tolerant model in describing relationship between diltiazem (Dil) concentrations in plasma and PR intervals on ECG in men.
Method:
Both plasma concentrations of Dil and changes of ECG were simultaneously determined after po Dil 90 mg in 8 men.
Results:
A two-compartmental pharmacokinetic model with first-order input gave a good fitting for the plasma concentration of Dil. Corresponding pharmacokinetic parameters were estimated: t1/2 beta, 5.9 +/- 1.0 h; MRT, 15.9 +/- 1.0 h; t0, 0.38 +/- 0.07 h; tmax, 2.7 +/- 0.4 h, and Cmax, 161 +/- 60 micrograms.L-1. The good fittings for plasma concentration-effect data were obtained with tolerant model E = S x C/(1 + T/T50). The pharmacodynamic parameters were given as follows: S, 829 +/- 293 s.g-1.L; Kt0, 0.037 +/- 0.024 h-1 and T50, 10 +/- 4 micrograms.L-1.
Conclusion:
Relationship between Dil concentrations in plasma and PR interval changes in men after po 90 mg was described using an acute tolerant model.