Primary tracheomalacia and gastroesophageal reflux in infants with cough

C W Callahan1

  • 1Tripler Army Medical Center, (MCHK-PE), Honolulu, HI 96859-5000, USA.

Clinical Pediatrics
|December 29, 1998
PubMed

Insights

Infant cough can stem from tracheomalacia (TM) and gastroesophageal reflux (GER). Early diagnosis and medical management, including bronchodilators, can effectively treat these conditions causing persistent infant cough.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology

Background:

  • Infant cough is uncommon and can indicate airway issues.
  • Central airway abnormalities impair secretion clearance.
  • Tracheomalacia (TM) and gastroesophageal reflux (GER) are potential causes of infant cough.

Observation:

  • Four infants presented with cough since birth.
  • Symptoms suggested central airway obstruction, such as tracheal cough.
  • Diagnoses of TM and GER were confirmed via barium esophagraphy and airway fluoroscopy.

Findings:

  • Tracheomalacia and GER can cause infant cough starting in the newborn period.
  • Diagnostic studies are often available to primary care providers.
  • These conditions showed responsiveness to medical management.

Implications:

  • Early identification of TM and GER is crucial for managing infant cough.
  • Conservative and medical therapies for GER, alongside bronchodilators, can be effective.
  • This highlights the importance of considering both airway and reflux issues in infantile cough.

Related Concept Videos

Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
Trachea01:22

Trachea

The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...