Related Experiment Video
Updated: Aug 4, 2026

Open Tracheostomy Gastric Acid Aspiration Murine Model of Acute Lung Injury Results in Maximal Acute Nonlethal Lung Injury
Published on: February 26, 2017
Primary tracheomalacia and gastroesophageal reflux in infants with cough
1Tripler Army Medical Center, (MCHK-PE), Honolulu, HI 96859-5000, USA.
Insights
Infant cough can stem from tracheomalacia (TM) and gastroesophageal reflux (GER). Early diagnosis and medical management, including bronchodilators, can effectively treat these conditions causing persistent infant cough.
Area of Science:
- Pediatric Pulmonology
- Gastroenterology
Background:
- Infant cough is uncommon and can indicate airway issues.
- Central airway abnormalities impair secretion clearance.
- Tracheomalacia (TM) and gastroesophageal reflux (GER) are potential causes of infant cough.
Observation:
- Four infants presented with cough since birth.
- Symptoms suggested central airway obstruction, such as tracheal cough.
- Diagnoses of TM and GER were confirmed via barium esophagraphy and airway fluoroscopy.
Findings:
- Tracheomalacia and GER can cause infant cough starting in the newborn period.
- Diagnostic studies are often available to primary care providers.
- These conditions showed responsiveness to medical management.
Implications:
- Early identification of TM and GER is crucial for managing infant cough.
- Conservative and medical therapies for GER, alongside bronchodilators, can be effective.
- This highlights the importance of considering both airway and reflux issues in infantile cough.
Abstract:
Cough is an uncommon sign in infants. Cough may result from the presence of abnormal secretions in the airway or abnormalities of the central airways that affect the infant's ability to clear normal secretions. Tracheomalacia (TM) and gastroesophageal reflux (GER) can both cause cough in infants. Four infants whose cough began in the newborn period were diagnosed with TM and GER. Symptoms of central airway obstruction (homophonous wheeze or tracheal cough) suggested the diagnoses. In three patients, the diagnosis was made by barium esophagraphy and airway fluoroscopy. The infants responded to conservative and medical therapy for GER and to nebulized bronchodilators. Tracheomalacia and GER cause cough in infants that begins in the newborn period. The diagnosis can often be made with studies available to the primary care provider, and the conditions are often responsive to medical management.
Related Concept Videos
Breathing
Trachea
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...
Pulmonary Cycle: Exhalation
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Gastroesophageal Reflux Disease

