Related Experiment Video

Updated: Jul 10, 2026

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
10:52

Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation

Published on: January 6, 2016

Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body

G Odorizzi1, M Babst, S D Emr

  • 1Division of Cellular and Molecular Medicine and Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla 92093-0668, USA.

Cell
|December 29, 1998
PubMed
Summary

Proper sorting of cell surface receptors into multivesicular bodies (MVBs) is crucial for their lysosomal degradation. This study reveals phosphoinositide signaling, specifically PtdIns(3,5)P2, is essential for cargo-selective MVB sorting in yeast.

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