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Mutators and long-term molecular evolution of pathogenic Escherichia coli O157:H7
T S Whittam1, S D Reid, R K Selander
1Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA. tsw1@psu.edu
Emerging Infectious Diseases
|December 29, 1998
Abstract:
It has been proposed that an increased mutation rate (indicated by the frequency of hypermutable isolates) has facilitated the emergence of Escherichia coli O157:H7. Analysis of the divergence of 12 genes shows no evidence that the pathogen has undergone an unusually high rate of mutation and molecular evolution.