Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multidrug-resistant tuberculosis]

H Saito1, R Amitani

  • 1Hiroshima Environment and Health Association, Japan.

Kekkaku : [Tuberculosis]
|December 29, 1998
PubMed
Summary
This summary is machine-generated.

Multidrug-resistant tuberculosis (MDR-TB) is increasing in the U.S.A. due to factors like faulty treatment, necessitating rapid diagnostic tests and advance planning in Japan. Early treatment is crucial, especially for HIV patients, given limited drug options.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased superoxide dismutase activity in erythrocyte in Parkinson's disease.

The Japanese journal of psychiatry and neurology·1992
Same author

[Application of ultrasonography in chest diseases--usefulness of ultrasonography and physiologic evaluation of low pressure vascular system].

Nihon Kyobu Shikkan Gakkai zasshi·1992
Same author

Recent advances in the study of hepatocellular carcinoma.

The Keio journal of medicine·1992
Same author

Evaluation of cor pulmonale on a modified short-axis section of the heart by magnetic resonance imaging.

The American review of respiratory disease·1992
Same author

Impaired secretion of the elongated mutant of protein C (protein C-Nagoya). Molecular and cellular basis for hereditary protein C deficiency.

The Journal of clinical investigation·1992
Same author

A 50-year-old man with ulcerative colitis and severe anemia.

The Keio journal of medicine·1992
Same journal

[EXTERNAL QUALITY ASSESSMENT OF ANTI-TUBERCULOSIS DRUG SUSCEPTIBILITY TESTING FOR DIAGNOSING EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS].

Kekkaku : [Tuberculosis]·2019
Same journal

[CLINICAL INVESTIGATION OF 6 CASES OF TUBERCULOUS SPONDYLITIS].

Kekkaku : [Tuberculosis]·2019
Same journal

[CONTROLLING TUBERCULOSIS IN FOREIGN-BORN PERSONS IN JAPAN].

Kekkaku : [Tuberculosis]·2019
Same journal

[EXPERIENCE OF USE OF NEW ANTI-TUBERCULOUS DRUG, DELAMANID IN MULTI- AND EXTENSIVELY DRUG RESISTANT TUBERCULOSIS CASES IN OUR HOSPITAL].

Kekkaku : [Tuberculosis]·2019
Same journal

[NONTUBERCULOUS MYCOBACTERIAL PULMONARY DISEASE].

Kekkaku : [Tuberculosis]·2019
Same journal

[MYCOBACTERIOSIS ASSOCIATED WITH ADMINISTRATION OF BIOLOGICS].

Kekkaku : [Tuberculosis]·2019
See all related articles

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Context:

  • Multidrug-resistant tuberculosis (MDR-TB) poses a growing global health threat, particularly in the U.S.A., with significant implications for patient care and public health strategies.
  • While Japan has not observed a similar increase, proactive measures are essential given international trends and the potential for nosocomial spread, especially among HIV patients.
  • Current diagnostic and treatment protocols for MDR-TB are lengthy, contributing to delayed interventions and increased transmission risks.

Purpose:

  • To highlight the rising incidence and contributing factors of MDR-TB in the U.S.A.
  • To emphasize the need for Japan to develop proactive countermeasures against MDR-TB.
  • To underscore the critical importance of rapid diagnostic tools and early treatment initiation for MDR-TB, particularly in co-infected HIV patients.

Related Experiment Videos

Summary:

  • MDR-TB, resistant to isoniazid and rifampicin, shows increasing incidence in the U.S.A. attributed to primary resistance or inadequate treatment.
  • Nosocomial outbreaks of MDR-TB, especially involving HIV patients, are a serious concern, linked to delayed diagnosis and susceptibility testing.
  • While Japan has seen stable MDR-TB rates, the U.S.A. experience necessitates advanced planning, including the development of rapid molecular diagnostic tests and careful drug selection based on resistance patterns.

Impact:

  • The study calls for the development of rapid molecular genetic tests for faster identification and susceptibility testing of MDR-TB strains.
  • It stresses the critical need for early treatment initiation, especially for MDR-TB patients with HIV, due to poorer prognoses.
  • The findings advocate for careful drug selection and management strategies for MDR-TB, considering drug resistance profiles and potential side effects.