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[The clinical effect after locally using mitomycin C during trabeculectomy in glaucoma]
1Department of Ophthalmology, Xiangya Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|January 1, 1997
Summary
Mitomycin C significantly enhances filtering bleb function after glaucoma surgery, improving intraocular pressure control and maintaining visual fields. This study shows higher success rates with mitomycin C compared to standard procedures.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Glaucoma Research
Background:
- Trabeculectomy is a common glaucoma surgery.
- Filtering bleb function is crucial for surgical success.
- Improving bleb longevity and efficacy remains a clinical challenge.
Purpose of the Study:
- To evaluate the efficacy of mitomycin C in enhancing filtering bleb function post-trabeculectomy.
- To compare intraocular pressure reduction and surgical success rates between mitomycin C and control groups.
Main Methods:
- A randomized controlled trial involving 44 patients (60 eyes) with moderate to late-stage glaucoma.
- Application of mitomycin C (0.2 mg/ml) soaked sponges to the scleral flap and bed.
- Follow-up duration of 1 to 12 months (mean 7.9 months).
Main Results:
- Functional filtering blebs were observed in 92.9% of the mitomycin C group versus 55.2% in the control group (P < 0.01).
- A significantly greater percentage decrease in intraocular pressure was noted in the mitomycin C group (P < 0.05).
- Higher overall surgical success rates and effective visual field maintenance were achieved with mitomycin C.
Conclusions:
- Mitomycin C application significantly improves the success rate of filtering blebs after trabeculectomy.
- The use of mitomycin C leads to better intraocular pressure control and visual field preservation in glaucoma patients.
- This adjunctive therapy offers a valuable strategy for optimizing outcomes in glaucoma surgery.