New diterpene isonitriles from the sponge Phakellia pulcherrima

Seven new diterpene isonitriles and isothiocyanates were isolated from the sponge Phakellia pulcherrima along with eight known ones. Six of the new compounds, 9-14, and the eight known ones, 1-8, belong to the kalihinol family of diterpenes. Structures were determined from spectroscopic data. This is the first report of diterpenes from sponges of this genus. All of the other kalihinol diterpenoids have been isolated from the sponge Acanthella cavernosa collected in diverse locations.