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Updated: Aug 13, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
[Spontaneous immuno-adherence in viral hepatitis]
Abstract:
Sera from patients with hepatitis, according to clinical and biochemical data, often give a spontaneous immune adherence (S.I.A.) with O human red blood cells. In 58% of the cases the test is positive and is associated with Australia (HBs) antigen in 6.7 to 9.5% of the patients. The titer cas reach 1/8192 and seems to follow the clinical evolution. S.I.A. also occurs at low titre (less than or equal to 1/32) in 18 to 30% of the cirrhosis tested, in 17 to 22% of various diseases and in 0 to 16% of different neoplasia. In spite of the fact that S.I.A. is not specific in its principle, it may be useful as a complementary test for detection and monitoring of viral hepatitis.
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