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Related Experiment Videos

Target position variability throughout prostate radiotherapy

L A Dawson1, K Mah, E Franssen

  • 1Department of Radiation Oncology, Toronto-Sunnybrook Regional Cancer Centre, University of Toronto, Ontario, Canada.

International Journal of Radiation Oncology, Biology, Physics
|December 30, 1998
PubMed
Summary
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Prostate and seminal vesicle position varied significantly during radiotherapy, with setup errors contributing substantially. Larger planning target volume margins are needed, but improved setup accuracy could reduce variability.

Area of Science:

  • Radiation Oncology
  • Medical Imaging
  • Prostate Cancer Treatment

Background:

  • External beam radiotherapy for prostate cancer requires precise targeting of the prostate and seminal vesicles.
  • Variability in organ position can compromise treatment accuracy and efficacy.
  • Understanding sources of variability is crucial for optimizing treatment planning.

Purpose of the Study:

  • To quantify the positional variability of the prostate and seminal vesicles during external beam radiotherapy.
  • To determine the contribution of setup error to overall target position variability.

Main Methods:

  • Forty-four planning CT scans were acquired weekly for six prostate cancer patients.
  • Prostate and seminal vesicle positions were analyzed relative to the treatment isocenter.

Related Experiment Videos

  • Setup error contribution to target variability was assessed by measuring position relative to bony landmarks.

    • Main Results:

    • Positional variability was greatest in the anterior-posterior (AP) direction, followed by cranial-caudal (CC) and mediolateral (ML).
    • Setup error significantly contributed to target position variability.
    • Deviations up to 15 mm (prostate) and 19 mm (seminal vesicles) were observed, necessitating large planning target volume (PTV) margins (e.g., 12.4 mm AP for prostate).

    Conclusions:

    • Significant target position variability exists during prostate radiotherapy, demanding substantial PTV margins around the clinical target volume (CTV).
    • Improved setup accuracy holds potential for reducing target position variability and optimizing treatment margins.