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Structure based design: novel spirocyclic ethers as nonpeptidal P2-ligands for HIV protease inhibitors
A K Ghosh1, K Krishnan, D E Walters
1Department of Chemistry, University of Illinois at Chicago 60607, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of novel spirocyclic ethers were designed to function as nonpeptidal P2-ligands for HIV-1 protease inhibitors. Incorporation of designed ligands in the (R)-(hydroxyethylamino)sulfonamide isostere afforded potent HIV protease inhibitors.