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A labeled guanidine ligand for studying sweet taste
1Department of Chemistry, Texas A & M University, College Station 77842, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A synthesis of a biotinylated-, coumarin-substituted-N,N'-diarylguanidine 1 is reported. This ligand has structural features conducive to studying sweet taste including a fluorescent tag to facilitate spectroscopic studies of binding to protein-receptors for sweet ligands and an anchor for affinity purification.