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Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
Published on: July 5, 2018
Hydroxamate-based inhibitors of low affinity IgE receptor (CD23) processing
S Bailey1, B Bolognese, D R Buckle
1SmithKline Beecham Pharmaceuticals, Epsom, Surrey, UK.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of hydroxamic acids related to the non-selective matrix metalloprotease inhibitor Batimastat is described, which inhibits the proteolytic cleavage of the low affinity IgE receptor from cell membrane preparations. Limited SAR studies suggest that the structural requirements for effective inhibition are distinct from those required for the inhibition of collagenase.

