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Synthesis and immunosuppressive activity of ruthenium complexes
C M Bastos1, K A Gordon, T D Ocain
1Procept, Inc., Cambridge, MA 02139, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin.