Related Experiment Videos
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist
T J Rosen1, K J Coffman, S McLean
1Central Research Division, Pfizer Inc., Groton, CT 06340, USA.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721, shows superior in vivo blockade of NK-1 receptor mediated responses.