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Potent antimitotic and cell growth inhibitory properties of substituted chalcones
S Ducki1, R Forrest, J A Hadfield
1Dept. of Chemistry, University of Manchester Institute of Science and Technology, UK.
Bioorganic & Medicinal Chemistry Letters
|January 1, 1999
Abstract:
A series of substituted chalcones was synthesised and screened for cytotoxic activity against the K562 human leukaemia cell line. (E)-3-(3"-Hydroxy-4"-methoxyphenyl)-2-methyl-1-(3',4',5'- trimethoxyphenyl)-prop-2-en-1-one [IC50 (K562) 0.21 nM] was found to be the most active. A relationship between the conformation and cytotoxicity of the chalcones is discussed.