Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel integrated optical sensor based on a grating coupler triplet

M Wiki1, R E Kunz, G Voirin

  • 1CSEM Centre Suisse d'Electronique et de Microtechnique SA, Zürich, Switzerland. max.wiki@csemne.ch

Biosensors & Bioelectronics
|January 1, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Thymic carcinoid tumor causing paraneoplastic Cushing syndrome. Diagnostic value of double-labelled tomoscintigraphy].

Presse medicale (Paris, France : 1983)·1996
Same author

Cytokines are increased in the rat hippocampus after serotonergic neuron degeneration and upregulate the expression of GDH, an enzyme involved in glutamate detoxification.

Journal of neuroimmunology·1996
Same author

Long-term toxicity of intravenous mercury injection.

Lancet (London, England)·1996
Same author

Increased Clara cell protein in serum of firefighters.

Clinical chemistry·1996
Same author

Selective isolation of transiently transfected cells from a mammalian cell population with vectors expressing a membrane anchored single-chain antibody.

Journal of immunological methods·1996
Same author

Low molecular weight proteinuria in human immunodeficiency virus-infected patients.

American journal of kidney diseases : the official journal of the National Kidney Foundation·1996
Same journal

Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection.

Biosensors & bioelectronics·2026
Same journal

A novel capillary-driven dual-mode imaging flow cytometry system for malaria parasite detection and quantification.

Biosensors & bioelectronics·2026
Same journal

Liver-targeted alkaline phosphatase-activatable fluorescent probe for imaging liver fibrosis and screening anti-fibrotic natural products.

Biosensors & bioelectronics·2026
Same journal

GLASS-seq: a gel-anchored, ligation-assisted, scalable biosensing platform for low-cost regional spatial transcriptomics.

Biosensors & bioelectronics·2026
Same journal

CRISPR/Cas12a-based dual-modal signal platform using MIL-101(Fe) for colorimetric and electron spin resonance detection of HPV-16 nucleic acid.

Biosensors & bioelectronics·2026
Same journal

Fully automated centrifugal microfluidic system for self-calibrating isothermal nucleic acid quantification.

Biosensors & bioelectronics·2026
See all related articles

A new symmetric grating coupler design creates robust integrated optical biosensors. This stable system achieves high sensitivity for detecting liquid properties and biomolecular binding without moving parts.

Area of Science:

  • Photonics and Sensor Technology
  • Biomolecular Interaction Analysis

Background:

  • Integrated optical biosensors offer high sensitivity but are often susceptible to mechanical instabilities.
  • Existing grating coupler designs can be complex and prone to environmental disturbances.

Purpose of the Study:

  • To present a novel, robust integrated optical biosensor approach.
  • To demonstrate a design that compensates for mechanical instabilities.
  • To achieve high sensitivity in biosensing applications.

Main Methods:

  • Utilized a symmetric grating coupler structure for inherent stability.
  • Developed an integrated optical sensor system with no moving parts.
  • Validated the sensor's performance by measuring refractive index and specific biomolecular binding.

Related Experiment Videos

Main Results:

  • The symmetric grating coupler effectively compensated for mechanical disturbances.
  • The sensor system demonstrated high sensitivity, comparable to existing grating coupler methods.
  • Successful detection of refractive index changes in liquids and specific binding of anti-chicken IgG to immobilized chicken IgG was achieved.

Conclusions:

  • The novel symmetric grating coupler approach enables robust and highly sensitive integrated optical biosensing.
  • This design overcomes limitations posed by mechanical instabilities in optical sensing.
  • The system shows significant potential for various label-free biosensing applications.