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Synthesis and biological properties of new 1 beta-methylcarbapenems
1Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R2 = NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety.