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Design and synthesis of thiol-reactive lipopeptides
C Boeckler1, B Frisch, F Schuber
1Laboratoire de Chimie Bioorganique, CNRS-UMR 7514, Université Louis Pasteur, Faculté de Pharmacie, Illkirch, France.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Lipopeptides are potent adjuvants that trigger an immune response against covalently conjugated low molecular mass antigens. We report here the design and synthesis of thiol-reactive lipopeptides (6, 7) which can be incorporated into liposomes and react, under mild conditions, with synthetic peptides carrying a thiol function.