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Biological properties of synthetic glycoconjugate mimics of heparin comprising different molecular spacers

C M Dreef-Tromp¹, J E Basten, M A Broekhoven

¹N.V. Organon Scientific Development Group, Oss, The Netherlands.

Bioorganic & Medicinal Chemistry Letters

|January 5, 1999

Abstract:

The in vitro antithrombotic activity of synthetic glycoconjugates I and II, comprising a flexible polyethylene glycol type and a rigid polyglucose type spacer, respectively, are compared to heparin.

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