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Novel H3 receptor antagonists. Sulfonamide homologs of histamine
R Wolin1, M Connolly, A Afonso
1Schering-Plough Research Institute, Department of Chemistry, Kenilworth, New Jersey 07033, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Sulfonamides derived from 4(5)-(omega-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding affinities were considerably weaker in the propyl series. Separation of the imidazole ring and the sulfonamide unit by a four- or five-carbon tether afforded potent H3 receptor antagonists.