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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
Identification of potent inhibitors of Plasmodium falciparum plasmepsin II from an encoded statine combinatorial
C D Carroll1, H Patel, T O Johnson
1Department of Biology, Pharmacopeia, Inc., Princeton, NJ 08540, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
An encoded 13,020-member combinatorial library was synthesized containing a statine core. Evaluation of this library with plasmepsin II, an aspartyl protease required for hemoglobin metabolism in the malaria parasite, led to the identification of potent and selective inhibitors as well as novel structure-activity relationships.

