Related Experiment Videos
Combinatorial chemistry of hydantoins
A Boeijen1, J A Kruijtzer, R M Liskamp
1Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.