Related Experiment Videos
Thalidomide analogs and PDE4 inhibition
G W Muller1, M G Shire, L M Wong
1Celgene Corporation, Warren, NJ 07059 USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-alpha are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.
Related Concept Videos
Articles linked to this work by shared authors, journal, and citation graph.
Glycaemic control and microvascular complications among paediatric type 2 diabetes mellitus patients in Hong Kong at 2 years after diagnosis.
Hong Kong medical journal = Xianggang yi xue za zhi·2024
Ovarian sex cord stromal tumor with annular tubules in a 7-year-old child: A case report.
Gynecologic oncology reports·2019
Evaluation of models predicting insignificant prostate cancer to select men for active surveillance of prostate cancer.
Prostate cancer and prostatic diseases·2015
Structure-activity profiling of indazole-based derivatives as spinster homolog 2 (Spns2)-dependent S1P release inhibitors.
Bioorganic & medicinal chemistry letters·2026
Synthesis and discovery of polyisopentenylated acylphloroglucinols with selective antiproliferative activity against breast cancer cells.
Bioorganic & medicinal chemistry letters·2026
Photocaging of a GPR52 agonist enables light-dependent receptor activation in cells.
Bioorganic & medicinal chemistry letters·2026
Discovery of potent, selective, and orally bioavailable monocyclic pyridine-based PKMYT1 inhibitors that synergize with CHK1 inhibition in replication-stressed cancer cells.
Bioorganic & medicinal chemistry letters·2026
Quinolin(on)es and pyridin(on)es as promising scaffolds against mycobacterial infections.
Bioorganic & medicinal chemistry letters·2026
An integrated in vitro and in silico approach to evaluate the safety and wound healing potential of Dracocephalum moldavica L. seed oil.
Toxicology in vitro : an international journal published in association with BIBRA·2026
Unraveling the allosteric inhibition mechanism of TLR2 by CU-CPT22: A combined DFT and enhanced sampling MD study.
Journal of molecular graphics & modelling·2026