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Design and synthesis of a pyridone-based phosphotyrosine mimetic
1Cadus Pharmaceutical Corporation, Tarrytown, NY 10591, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
A novel pyridone-based tyrosine analog, 6, has been designed to mimic the binding interaction of SH2 domains with phosphotyrosine (pTyr) containing peptides. Synthesis of 6 features a key Pd catalyzed coupling of beta-iodoalanine with phosphonomethyl 4-pyridone triflate.