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Facile and improved synthesis of 4 beta-aminopodophyllotoxin congeners
A Kamal1, N L Gayatri, N V Rao
1Indian Institute of Chemical Technology, Hyderabad, India.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
An efficient synthesis of 4 beta-aminopodophyllotoxin from 4 beta-bromopodophyllotoxin using ammonia, and also a facile synthesis of 4 beta-amino-4'-O-demethylpodophyllotoxin from 4 beta-azidopodophyllotoxin by simultaneous azido reduction and selective demethylation at 4'-position employing chlorotrimethylsilane and sodium iodide, has been described. These are potential precursors for the various 4 beta-amino analogs of podophyllotoxin possessing DNA topoisomerase II inhibition activity.