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Design and synthesis of SH3 domain binding ligands: modifications of the consensus sequence XPpXP
D J Witter1, S J Famiglietti, J C Cambier
1Cadus Pharmaceutical Corporation, Tarrytown, NY 10591, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
Spirolactam-based Pro-Pro mimetics incorporated in the consensus sequence XPpXP, lead to effective nonpeptide ligands of SH3 domains.