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Anthelmintic beta-hydroxyketoamides (BKAs)
B H Lee1, M F Clothier, F E Dutton
1Animal Health Discovery Research, Pharmacia & Upjohn, Inc., Kalamazoo, MI 49001, USA.
Bioorganic & Medicinal Chemistry Letters
|January 5, 1999
Abstract:
We have prepared several anthelmintic coumarins based on the beta-hydroxyketoamide (BKA) template and have shown that this template remains valid over a wide range of changes to the coumarin moiety allowing for the inclusion of carbocyclic, bicyclic, and heterocyclic rings.