Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human glutathione S-transferases

R Whalen1, T D Boyer

  • 1Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Seminars in Liver Disease
|January 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversal of hepatorenal syndrome type 1 with terlipressin plus albumin vs. placebo plus albumin in a pooled analysis of the OT-0401 and REVERSE randomised clinical studies.

Alimentary pharmacology & therapeutics·2017
Same author

Autoimmune hepatitis in African Americans: presenting features and response to therapy.

The American journal of gastroenterology·2002
Same author

Sequential implantation of two Helex septal occluder devices in a patient with complex atrial septal anatomy.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions·2001
Same author

Pharmacologic treatment of portal hypertension: past, present, and future.

Hepatology (Baltimore, Md.)·2001
Same author

Serum hyaluronic acid in patients with veno-occlusive disease following bone marrow transplantation.

Bone marrow transplantation·2001
Same author

Management of variceal bleeding.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2001
Same journal

Hepatosystemic T cell licensing in MASLD-associated neuroinflammation.

Seminars in liver disease·2026
Same journal

Endothelial Cell Therapy for the Acute and Chronic Liver Disease.

Seminars in liver disease·2026
Same journal

Neutrophils in Liver Diseases: Functions and Challenging Therapies.

Seminars in liver disease·2026
Same journal

Expert Practical Recommendations for Hepatocellular Carcinoma.

Seminars in liver disease·2026
Same journal

Optimizing Liver Cancer Care Through BCLC Principles.

Seminars in liver disease·2026
Same journal

Patient-Derived Models of Liver Cancer to Inform Clinical Treatment Paradigms: Recent Updates.

Seminars in liver disease·2026
See all related articles

Human glutathione S-transferases (GSTs) are key detoxification enzymes. Their genetic variations influence cancer susceptibility, highlighting their protective role against toxic substances.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Toxicology
  • Genetics

Background:

  • Human glutathione S-transferases (GSTs) are crucial soluble enzymes involved in detoxification.
  • GSTs catalyze conjugation and reduction reactions, facilitating the excretion of toxic electrophiles and carcinogens.
  • Understanding GST function is vital for comprehending cellular defense mechanisms against toxins.

Purpose of the Study:

  • To review the functional diversity and enzymatic mechanisms of human GSTs.
  • To explore the regulation of human GST gene expression and its differences from rodents.
  • To examine the implications of human GST polymorphisms in cancer susceptibility.

Main Methods:

  • Review of existing literature on GST cloning and structural determination.

Related Experiment Videos

  • Analysis of studies on GST gene expression regulation, including inducers like reactive oxygen species.
  • Examination of research linking GST polymorphisms to cancer risk and environmental factors.

    • Main Results:

    • Human GSTs exhibit functional diversity, utilizing reduced glutathione (GSH) for detoxification.
    • Structural data provide insights into the enzymatic mechanisms of GSTs.
    • Human GST gene regulation differs from rodents, and common polymorphisms are associated with increased cancer risk, especially with co-factors like smoking.

    Conclusions:

    • Human GSTs play a significant role in protecting cells from electrophilic injury.
    • Genetic variations in GSTs can modify an individual's susceptibility to diseases like cancer.
    • Further research is ongoing to fully elucidate the protective roles of GSTs.