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Related Experiment Videos

Particle size distributions from multiparticulate dissolution

M V Dali1, J T Carstensen

  • 1School of Pharmacy, University of Wisconsin-Madison 53706, USA.

Drug Development and Industrial Pharmacy
|January 7, 1999
PubMed
Summary
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This study introduces a novel method using short-term dissolution data to determine particle size distribution in powders. This technique accurately estimates particle dimensions, offering a valuable tool for powder characterization.

Area of Science:

  • Physical Chemistry
  • Materials Science
  • Powder Technology

Background:

  • Accurate particle size distribution is crucial for powder performance.
  • Traditional methods like microscopy can be time-consuming and labor-intensive.
  • Dissolution testing offers a potential alternative for rapid characterization.

Purpose of the Study:

  • To develop and validate a theoretical framework for assessing particle size distribution using dissolution data.
  • To demonstrate the calculation of distribution parameters (mean and standard deviation) from dissolution experiments.
  • To apply the method to crystalline powders, specifically oxalic acid dihydrate.

Main Methods:

  • Theoretical modeling based on polydispersity and particle geometry (parallelepiped).

Related Experiment Videos

  • Utilizing cubic expressions for undissolved amount and fraction over time.
  • Calculating moments of the particle dimension distribution function.
  • Experimental validation using oxalic acid dihydrate dissolution and microscopy.

    • Main Results:

    • The theoretical model accurately predicts particle size distribution parameters from dissolution data.
    • First and second moments of the distribution were successfully evaluated.
    • The method provided good agreement with microscopy-based measurements for oxalic acid dihydrate.
    • An estimation of the mean height-to-breadth ratio was obtained.

    Conclusions:

    • Short-term dissolution data can reliably assess particle size distribution in powders.
    • The developed method offers an efficient alternative to microscopy for powder characterization.
    • This approach is applicable to various crystalline particle shapes (needles, plates, prisms).