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Chitosan: a unique polysaccharide for drug delivery
Drug Development and Industrial Pharmacy
|January 7, 1999
Summary
This review explores chitosan, a biopolymer, as a versatile pharmaceutical drug carrier for various delivery systems. It covers oral formulations, parenteral devices, and sustained-release applications via nasal, ophthalmic, transdermal, and implant routes.
Area of Science:
- Biomaterials Science
- Pharmaceutical Technology
- Drug Delivery
Background:
- Chitosan is a biocompatible and biodegradable polysaccharide with significant potential in pharmaceutical applications.
- Its unique properties make it suitable for various drug delivery systems.
Purpose of the Study:
- To review the diverse applications of chitosan as a pharmaceutical drug carrier.
- To highlight chitosan's utility in oral, parenteral, and sustained-release drug delivery.
Main Methods:
- Literature review of scientific publications on chitosan in drug delivery.
- Analysis of chitosan's role as an excipient in oral formulations.
- Examination of chitosan in parenteral drug delivery devices.
- Discussion of chitosan-based sustained-release systems for multiple administration routes.
Main Results:
- Chitosan serves as an effective excipient in direct tableting for oral formulations.
- It is a viable vehicle for parenteral drug delivery devices.
- Chitosan enables the development of sustained-release systems for nasal, ophthalmic, transdermal, and implantable applications.
Conclusions:
- Chitosan is a highly versatile biopolymer for pharmaceutical drug delivery.
- Its applications span from oral and parenteral routes to advanced sustained-release systems.
- Further research into chitosan-based drug carriers promises enhanced therapeutic outcomes.