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Bioabsorbable polymers for implantable therapeutic systems

V R Sinha1, L Khosla

  • 1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.

Drug Development and Industrial Pharmacy
|January 7, 1999
PubMed
Summary
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Biodegradable implantable drug delivery systems offer improved patient compliance over nondegradable options. These advanced systems provide controlled, long-term drug release without requiring surgical removal.

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Traditional subcutaneous implants use nondegradable polymers, necessitating surgical removal and offering imprecise drug release.
  • These limitations negatively impact patient acceptance and compliance for long-term therapies.
  • Research focuses on developing advanced drug delivery systems to overcome these drawbacks.

Purpose of the Study:

  • To review current research on implantable therapeutic systems utilizing bioabsorbable polymers.
  • To discuss the characteristics of various bioabsorbable polymers for controlled drug delivery.
  • To highlight the application of these systems with diverse biologically active agents.

Main Methods:

  • Evaluation of various bioabsorbable polymers including hydrogels, polylactic acid, polyglycolic acid copolymers, poly(orthoesters), polyanhydrides, poly(E-caprolactone), and polyurethanes.

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  • Study of drug release profiles and degradation characteristics in biological tissues.
  • Assessment of biocompatibility, non-irritating, and non-carcinogenic properties of the materials.

    • Main Results:

    • Biodegradable implantable systems enable prolonged drug release with simultaneous or subsequent polymer degradation into harmless byproducts.
    • These systems eliminate the need for surgical removal post-therapy, significantly enhancing patient acceptability.
    • Successful application demonstrated with various drugs, including anticancer agents, hormones, anti-inflammatories, and contraceptives.

    Conclusions:

    • Bioabsorbable polymers represent a significant advancement in implantable drug delivery, improving upon nondegradable systems.
    • These novel systems offer precise control over drug release rates and duration, enhancing therapeutic outcomes.
    • The development of these advanced drug delivery platforms holds great promise for improved patient compliance and treatment efficacy.