[Phenamine sterotypy as a drug-induced model of psychopathology]

Stereotype movements in cats following the administration of bid dosages of phenamine is accompanied by crude disorders of conditioned avoidance with an increase of intrasignal reactions, a weakening of differentiated inhibition and an inhibition of avoidance responses due to low frequency irritation of the caudate nucleus. Caffeine even in large dosages does not possess such properties. Phenamine as in caudectomia decreases the amount of monomodel neurons in the neocortex, as well as group postdischarges in the caudate response of neurons. It is assumed that many indices of phenamine stereotypicity, as a possible model of psychopathology, may be explained by disturbances of the filtering and retention functions of the caudate nucleaus.