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Effects of a standard hyperbaric oxygen treatment protocol on pulmonary function
E Thorsen1, L Aanderud, T B Aasen
1Dept of Hyperbaric Medicine, Haukeland Hospitak, Bergen, Norway.
The European Respiratory Journal
|January 7, 1999
Summary
Hyperbaric oxygen (HBO) therapy can cause temporary, minor reductions in lung function, specifically in small airways. These effects are not clinically significant for patients undergoing standard HBO treatment protocols.
Area of Science:
- Pulmonary Medicine
- Hyperbaric Medicine
- Respiratory Physiology
Background:
- Hyperbaric oxygen (HBO) therapy use for non-diving related conditions is increasing.
- Pulmonary oxygen toxicity is a known risk, but cumulative effects of standard HBO protocols are not well-quantified.
Purpose of the Study:
- To quantify the effects of a standard hyperbaric oxygen (HBO) treatment protocol on lung function.
- To assess pulmonary oxygen toxicity in patients receiving HBO therapy for non-diving related disorders.
Main Methods:
- Twenty patients underwent 21 daily HBO treatments (240 kPa for 90 min).
- Lung function tests (dynamic lung volumes, expiratory flows, TL,CO) were measured pre-treatment, during treatment (days 7, 14, 21), and post-treatment (3-4 weeks).
Main Results:
- Progressive reduction in FEV1, FEF25-75%, and FEV50/75% observed during HBO treatment.
- FEV1 reduced by 4.4% and FEF25-75% by 10.3% on day 21.
- Transfer factor of the lung for carbon monoxide (TL,CO) showed a slight, transient reduction.
- Lung function partially normalized post-treatment; no changes in FVC or PEF.
Conclusions:
- Standard HBO protocols can cause mild, temporary small airway dysfunction.
- These pulmonary effects are not clinically significant for patients unless repeated treatment courses are administered.
- The findings suggest HBO therapy is safe regarding pulmonary toxicity within standard treatment limits.